Trials
MRD trials
The curated index is a sourced list of studies. Accruing is the live ClinicalTrials.gov recruiting set. DYNAMIC-III is not in the curated index because it is registered in Australia and New Zealand, not with an NCT id.
Recruiting interventional studies whose public record uses ctDNA or MRD to guide treatment, or lists it as a primary endpoint. 110 studies from 454 registry hits. Last synced Nov 14, 2026, 9:51 PM EST.
A Single Arm Phase II Trial in p16-positive Oropharynx Cancer of Selective Dose De-escalation of nodAl VolumEs at Minimal Risk and Primary Site Disease (SAVED)
University of Maryland, Baltimore · 4 locations · Updated 2026-11-06
Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer
Natera, Inc. · 50 locations · Updated 2026-11-05
Circulating Tumor DNA Methylation-Guided Adjuvant Therapy Decision-Making in Patients With Resectable Colorectal Cancer Liver Metastases After Resection
Fudan University · 1 locations · Updated 2026-11-04
A Study to Compare Linvoseltamab Monotherapy and Linvoseltamab + Carfilzomib Combination Therapy With Standard-of-Care Combination Regimens in Adult Participants With Relapsed/Refractory Multiple Myeloma (RRMM)
Regeneron Pharmaceuticals · 53 locations · Updated 2026-11-04
Befotertinib Plus Chemotherapy With an MRD-guided Adaptive Strategy for Treatment Escalation and Response Optimization in EGFR-mutated NSCLC Patients
Guangzhou University of Traditional Chinese Medicine · 2 locations · Updated 2026-11-04
Minimal Residual Disease Guided Maintenance Therapy With Belantamab Mafodotin and Lenalidomide After Autologous Hematopoietic Cell Transplantation in Patients With Newly Diagnosed Multiple Myeloma
M.D. Anderson Cancer Center · 1 locations · Updated 2026-11-02
Safe De-escalation of Chemotherapy for Stage 1 Breast Cancer
Royal Marsden NHS Foundation Trust · 13 locations · Updated 2026-10-29
MRD-Guided Postoperative Surveillance and Adaptive Treatment for Resectable Lung Cancer
Peking University People's Hospital · 1 locations · Updated 2026-10-26
Circulating Tumor DNA Guided Boost Therapy in Early Triple Negative Breast Patients With Residual Disease After Neoadjuvant Therapy
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · 1 locations · Updated 2026-10-23
ctDNA-Guided Sunitinib And Regorafenib Therapy for GIST
University of Miami · 1 locations · Updated 2026-10-23
ctDNA-Guided Therapy for Relapsed/Refractory Hodgkin Lymphoma
Michael Spinner, MD · 6 locations · Updated 2026-10-20
Fluorescence Image Guided Surgery Followed by Intraoperative Photodynamic Therapy for Improving Local Tumor Control in Patients With Locally Advanced or Recurrent Colorectal Cancer
Roswell Park Cancer Institute · 1 locations · Updated 2026-10-15
ctDNA-Guided Immunotherapy for dMMR/MSI-H Colon Cancer
Fudan University · 1 locations · Updated 2026-09-25
A Pilot Study of ctDNA-Guided Immune Checkpoint Inhibitor Duration in Patients With Advanced Melanoma.
Rutgers, The State University of New Jersey · 1 locations · Updated 2026-09-21
Circulating Tumor DNA
Yale University · 7 locations · Updated 2026-09-21
ctDNA-guided Addition of Ipilimumab to Patients Receiving Nivolumab and Relatlimab
NYU Langone Health · 1 locations · Updated 2026-08-24
HERizon-Breast: A ctDNA-Guided Adaptive Study of Sequential Anti-HER2 Therapies and CNS Prophylaxis to Induce Long-Term Remission
Memorial Sloan Kettering Cancer Center · 7 locations · Updated 2026-08-20
MRD-Guided BCMA/CD3 Bispecific Antibody Treatment After Stem Cell Transplant for Newly Diagnosed Multiple Myeloma
Institute of Hematology & Blood Diseases Hospital, China · 1 locations · Updated 2026-08-07
ctDNA-driven Adaptive Proton Craniospinal Irradiation in Non-Small Cell Lung Cancer With Leptomeningeal Metastasis After Resistance to Third-Generation TKIs in the Consolidation Phase
Shuanghu Yuan · 3 locations · Updated 2026-08-07
Measurable Residual Disease-Guided Post-Transplant Elranatamab Maintenance
Washington University School of Medicine · 1 locations · Updated 2026-08-06
CDK4/6 Inhibitors Combined With Endocrine Therapy for Neoadjuvant Treatment
Peking University People's Hospital · 1 locations · Updated 2026-07-13
ctDNA-Guided De-Escalation of Adjuvant Chemotherapy With Dalpiciclib in HR-Positive/HER2-Negative Breast Cancer
Peking University People's Hospital · 1 locations · Updated 2026-07-13
A Study of MRD-Guided Zanubrutinib Plus Sonrotoclax in Treatment-Naïve, High-Risk CLL/SLL Patients
The First Affiliated Hospital with Nanjing Medical University · 1 locations · Updated 2026-06-26
Frontline T-cell Engager vs Autologous Stem Cell Transplant (ASCT) and Measurable Residual Disease (MRD)-Guided Sequential Intensification thERapy in Multiple Myeloma
SCRI Development Innovations, LLC · 11 locations · Updated 2026-06-04
A ctDNA-guided Phase II Trial of Osimertinib in Combination With Sacituzumab Tirumotecan in EGFR-mutated Advanced NSCLC Patients With Positive ctDNA After lead-in Osimertinib Monotherapy
Guangdong Association of Clinical Trials · 4 locations · Updated 2026-05-26
Study of ctDNA Guided Change in Tx for Refractory Minimal Residual Disease in Colon Adenocarcinomas
University of California, Irvine · 1 locations · Updated 2026-05-11
RESPONSE: Colorectal Cancer Survivors' Follow-up Care - Now Digital and Need-based
University of Aarhus · 9 locations · Updated 2026-05-04
Randomized Trial of Plasma ctDNA Methylation-Guided Adjuvant Therapy in T4N0 and Low-Risk Stage III Colorectal Cancer
Fudan University · 1 locations · Updated 2026-05-01
A Randomized Controlled Trial of Plasma ctDNA Methylation-Guided Adjuvant Chemotherapy Decision-Making in High-Risk Stage III (T4N+ or T1-3N2) Colorectal Cancer
Fudan University · 1 locations · Updated 2026-05-01
Randomized Controlled Study of Plasma ctDNA Methylation-Guided Adjuvant Chemotherapy in Stage I/Low-Risk Stage II Colorectal Cancer
Fudan University · 1 locations · Updated 2026-05-01
FOLICOLOR TRIAL: Following Therapy Response Through Liquid Biopsy in Metatstatic Colorectal Cancer Patients
University Hospital, Antwerp · 9 locations · Updated 2026-04-30
ctDNA-MRD Guided Consolidation Toripalimab in Stage IB-IIIA NSCLC
Sun Yat-sen University · 1 locations · Updated 2026-04-23
Dynamic Circulating Tumor DNA Monitoring to Guide Systemic Therapy in Gastric Cancer
Fudan University · 1 locations · Updated 2026-04-08
Implementing ctDNA and Circular DNA in Patients With Localized Pancreatic Cancer
Copenhagen University Hospital at Herlev · 5 locations · Updated 2026-03-27
Pre-emptive Therapy With DEC-C to Improve Outcomes in MDS Patients With Measurable Residual Disease Post Allogeneic Hematopoietic Cell Transplant
Washington University School of Medicine · 1 locations · Updated 2026-03-23
MRD-guided Maintenance Post-HCT: Gilteritini vs Sorafenib
The First Affiliated Hospital of Soochow University · 2 locations · Updated 2026-03-20
ctDNA-MRD Guided Escalation of Ivonescimab and Docetaxel in Advanced NSCLC With Long-Term Responses to First-line Immunotherapy (CR1STAL-Adaptive)
Second Xiangya Hospital of Central South University · 20 locations · Updated 2026-03-09
ctDNA-guided Treatment Decision-making
Fudan University · 1 locations · Updated 2026-02-06
Gilteritinib Plus VA Followed By Consolidation Chemotherapy in Newly Diagnosed FLT3-ITD+ AML
First Affiliated Hospital of Zhejiang University · 1 locations · Updated 2026-02-04
ctDNA-guided Therapy Optimization in Newly Diagnosed DLBCL
Hua-Jay J Cherng, MD · 1 locations · Updated 2026-01-23
Circulating Tumor DNA Guided Treatment Monitoring in Advanced Lung Cancer
Zealand University Hospital · 5 locations · Updated 2026-01-09
Adaptive Adjuvant Sintilimab Therapy Guided by MRD (ADAPT Lung)
Guangdong Association of Clinical Trials · 2 locations · Updated 2026-01-05
A Study of Osimertinib-based Adaptive Treatment Guided by ctDNA EGFRm+ Monitoring in NSCLC
Shanghai Chest Hospital · 1 locations · Updated 2025-11-26
A Study to Evaluate the Impact of Mosunetuzumab Consolidation for Older Patients With Diffuse Large B-cell Lymphoma (DLBCL) Who Have Detectable Amounts of ctDNA (Circulating Tumor DNA) at the End of Treatment With Pola-R-mini-CHP
Danielle Wallace · 1 locations · Updated 2025-10-20
Circulating Tumor DNA Methylation Guided Postoperative Follow-up Strategy for Non-metastatic Colorectal Cancer
Fudan University · 1 locations · Updated 2025-09-18
Adjuvant Pancreatic Therapy Guided by MRD
Ruijin Hospital · 1 locations · Updated 2025-07-15
ctDNA-Guided Cetuximab or Bevacizumab Plus Trifluridine/Tipiracil in RAS/BRAF Wild-Type mCRC
Sun Yat-sen University · 1 locations · Updated 2025-06-24
PROPHET Study: ctDNA-Guided Personalized Induction Immunochemotherapy for NSCLC
Sun Yat-sen University · 1 locations · Updated 2025-05-23
Standard Surveillance vs. Intensive Surveillance in Early Breast Cancer
Prof. Wolfgang Janni · 1 locations · Updated 2025-05-02
The ctDNA-RECIST Trial Part One
Karen-Lise Garm Spindler · 2 locations · Updated 2025-05-01
Liquid Biopsy-Based Novel Modality for Postoperative Management of Lung Cancer
Peking University People's Hospital · 1 locations · Updated 2025-04-16
Safety and Efficacy of Early Second Infusion of Axi-cel Based on ctDNA for R/R Large B - Cell Lymphoma
Zhujiang Hospital · 1 locations · Updated 2025-03-30
The Relapse from MRD Negativity As Indication for Treatment (REMNANT) Study
Oslo University Hospital · 13 locations · Updated 2025-03-20
Circulating Tumor DNA-guided Neoadjuvant Treatment Strategy for Locally Advanced Rectal Cancer
Peking Union Medical College Hospital · 1 locations · Updated 2024-12-24
Developing ctDNA Guided Adjuvant Therapy for Gastrooesophageal Cancer
University of Southampton · 14 locations · Updated 2024-11-12
Ciltacabtagene Autoleucel in High-Risk Smoldering Multiple Myeloma
PETHEMA Foundation · 1 locations · Updated 2024-10-26
ctDNA-guided Selection of Adjuvant Chemotherapy Regimens for Elderly Colon Cancer Patients After Surgery: A Single-center, Randomized, Controlled Study
Zhejiang Cancer Hospital · 1 locations · Updated 2024-09-24
NOAC9 - Circulating Tumor DNA Guided Follow-Up in Anal Cancer
Aarhus University Hospital · 13 locations · Updated 2024-08-14
OPTIMIzation of Treatment SElection and Follow up in Oligometastatic Colorectal Cancer
Karen-Lise Garm Spindler · 2 locations · Updated 2024-08-14
Circulating Tumor DNA Methylation Guided Postoperative Adjuvant Chemotherapy for High-risk Stage II/III Colorectal Cancer
Fudan University · 1 locations · Updated 2024-05-20
Circulating Tumor DNA Methylation Guiding Postoperative Adjuvant Chemotherapy in Stage III Colorectal Cancer
Sir Run Run Shaw Hospital · 1 locations · Updated 2024-05-17
Genomic Biomarker-guided Neoadjuvant Therapy for Prostate Cancer (SEGNO)
The First Affiliated Hospital of Xiamen University · 1 locations · Updated 2024-04-26
MRD-guided Deferred Adjuvant Therapy in Resectable Early-stage Colon Cancer
Sun Yat-sen University · 1 locations · Updated 2024-01-12
DVRd in the Treatment of Patients With Newly Diagnosed Double-hit Multiple Myeloma
Institute of Hematology & Blood Diseases Hospital, China · 1 locations · Updated 2023-12-06
Venetoclax, Rituximab and Ibrutinib in TN Patients With CLL Undetectable Minimal Residual Disease (uMRD) in Treatment-naïve Patients With Chronic Lymphocytic Leukemia (CLL)
Paolo Ghia · 1 locations · Updated 2023-10-04
ctDNA-guided Adjuvant Chemotherapy in Liver Metastasis of Colorectal Cancer
Sixth Affiliated Hospital, Sun Yat-sen University · 1 locations · Updated 2023-04-18
The Value of Molecular Residual Disease Monitoring Based on ctDNA in Borderline Resectable or Locally Advanced Pancreatic Cancer
Peking Union Medical College Hospital · 1 locations · Updated 2023-04-12
The Value of Molecular Residual Disease Monitoring Based on ctDNA in Resected Pancreatic Cancer
Peking Union Medical College Hospital · 1 locations · Updated 2023-04-12
Postoperation Maintenance Therapy for Resectable Liver Metastases of Colorectal Cancer Guided by ctDNA
Sixth Affiliated Hospital, Sun Yat-sen University · 1 locations · Updated 2023-04-04
MRD-guided Adjuvant Tislelizumab and Chemotherapy in Resected Stage IIA-IIIB NSCLC
The First Affiliated Hospital of Zhengzhou University · 1 locations · Updated 2023-03-17
Systemic Neoadjuvant and Adjuvant Control by Precision Medicine in Rectal Cancer
Helsinki University Central Hospital · 2 locations · Updated 2023-03-06
Circulating Tumor DNA Guided Adjuvant Chemotherapy for Colon Cancer
Peking University Cancer Hospital & Institute · 1 locations · Updated 2022-09-07
Anti-CEA CAR-T Cells to Treat Colorectal Liver Metastases
Changhai Hospital · 1 locations · Updated 2022-03-11
EUS Guided HVA and PVA for Circulating Tumor DNA in Patients
Chinese University of Hong Kong · 1 locations · Updated 2021-03-04
PREDICT-RD: ctDNA Surveillance in TNBC With Residual Disease
UNC Lineberger Comprehensive Cancer Center · 2 locations · Updated 2026-11-13
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
NRG Oncology · 1085 locations · Updated 2026-11-04
Kadcyla And Neratinib for Interception of HER2+ Breast Cancer With Molecular Residual Disease
University Health Network, Toronto · 1 locations · Updated 2026-10-13
Molecular Residual Disease Assessment in a Representative Diverse Population of Patients With Early-stage Breast Cancer
UNC Lineberger Comprehensive Cancer Center · 1 locations · Updated 2026-09-02
Biomarkers to Detect Endocrine Therapy Resistance
University of Wisconsin, Madison · 1 locations · Updated 2026-08-25
Imlunestrant and Abemaciclib for the Treatment of Estrogen Receptor Positive Breast Cancer in Patients With Minimal Residual Disease, MIRI Trial
Jonsson Comprehensive Cancer Center · 1 locations · Updated 2026-08-20
Capecitabine in ER+/HER2-negative Breast Cancer
University Health Network, Toronto · 1 locations · Updated 2026-08-18
Serial Circulating Tumor DNA (ctDNA) Monitoring During Adjuvant Capecitabine in Early Triple-negative Breast Cancer
Stanford University · 1 locations · Updated 2026-08-12
Circulating Tumor DNA to Guide Changes in Standard of Care Chemotherapy
Vanderbilt-Ingram Cancer Center · 1 locations · Updated 2026-06-24
ctDNA in HER2+ EBC Neoadjuvant Treatment
Shanghai Jiao Tong University School of Medicine · 1 locations · Updated 2026-03-24
Tirzepatide Weight Loss for MRD+ Early Breast Cancer
Baylor Research Institute · 1 locations · Updated 2026-02-12
Interest of Circulating Tumor DNA in Digestive and Gynecologic/Breast Cancer
Poitiers University Hospital · 1 locations · Updated 2025-12-24
A Study of Circulating Tumor DNA (ctDNA) Testing for People With B-Cell Lymphoma
Memorial Sloan Kettering Cancer Center · 7 locations · Updated 2025-12-18
Sustainable and Efficient Platform Trial of New Therapeutic Development for Early Breast Cancer
Nagoya City University · 1 locations · Updated 2025-11-20
PHOENIX DDR/Anti-PD-L1 Trial: A Pre-surgical Window of Opportunity and Post-surgical Adjuvant Biomarker Study of DNA Damage Response Inhibition With or Without Anti-PD-L1 Immunotherapy in Patients With Neoadjuvant Treatment Resistant Residual Triple Negative Breast Cancer
Institute of Cancer Research, United Kingdom · 6 locations · Updated 2025-08-11
ctDNA Monitoring in Patients With HCC and mCRC
Medical University of Warsaw · 1 locations · Updated 2025-06-03
A Randomized Secondary Adjuvant Treatment Intervention Study Comparing Trastuzumab-Deruxtecan to SOC Therapy in eBC Patients With Molecular Relapse
Prof. Wolfgang Janni · 1 locations · Updated 2025-05-02
A Trial of Early Detection of Molecular Relapse With Circulating Tumour DNA Tracking and Treatment With Palbociclib Plus Fulvestrant Versus Standard Endocrine Therapy in Patients With ER Positive HER2 Negative Breast Cancer
Royal Marsden NHS Foundation Trust · 49 locations · Updated 2024-12-05
Pilot Comparing ctDNA IDV vs. SPV Sample in Pts Undergoing Biopsies for Hepatobiliary and Pancreatic Cancers
University of California, Irvine · 1 locations · Updated 2026-08-31
Clinical Utility of ctDNA in Detecting Resistance Mechanisms and Delivering Precision Medicine to Cancer Patients
Royal Marsden NHS Foundation Trust · 1 locations · Updated 2026-06-29
MRD-Adaptive Guided Immunotherapy With CAR-T for Transplant-Ineligible Patients With Multiple Myeloma
Institute of Hematology & Blood Diseases Hospital, China · 1 locations · Updated 2026-10-27
A Study of PET Adapted Therapy and Non-invasive Monitoring for Previously Untreated Limited Stage Diffuse Large B Cell Lymphoma
University of Rochester · 1 locations · Updated 2026-10-13
Personalized Reduction of Chemotherapy Intensity Through ctDNA Evaluation for the Treatment of Patients With Advanced Hodgkin Lymphoma
University of Washington · 6 locations · Updated 2026-09-09
Pre-transplant Purging and Post-transplant MRD-guided Maintenance Therapy With Elranatamab in Patients With High-risk Multiple Myeloma
M.D. Anderson Cancer Center · 1 locations · Updated 2026-08-10
Hyperfractionated Dual Equivalent Fractionated Radiation Therapy
Yale University · 1 locations · Updated 2026-06-22
Chidamide Maintenance for MRD-Positive Double-Expressor DLBCL in First Complete Remission
Rong Tao · 1 locations · Updated 2026-06-18
Defining ctDNA Metrics in Posttransplant Lymphoproliferative Disorder (PTLD)
Jennifer Amengual · 2 locations · Updated 2026-05-27
Feasibility Trial of Glofitamab in a Response Adapted Approach Incorporating Interim FDG PET and ctDNA to Optimize Primary Therapy of DLBCL (GRAIL)
University Health Network, Toronto · 3 locations · Updated 2026-04-24
Molecular Residual Disease Interception in Locoregionally-Advanced High Risk HPV+ and HPV- HNSCC
University Health Network, Toronto · 1 locations · Updated 2026-10-05
A Comprehensive Multiomic Biomarker Evaluation Across Two Single-arm Cohorts to Elucidate Mechanisms of Response and Resistance in Recurrent/Metastatic (R/M) Head and Neck Squamous Cell Carcinoma (HNSCC)
University Health Network, Toronto · 1 locations · Updated 2026-10-01
ctDNA Testing to Inform Standard-of-Care Treatment Decisions in People With Endometrial Cancer
Memorial Sloan Kettering Cancer Center · 7 locations · Updated 2026-09-25
Liquid Biopsies in Esophageal Cancer
Universitaire Ziekenhuizen KU Leuven · 4 locations · Updated 2026-06-01
A Multicenter Prospective Study Evaluating Concurrent Chemoradiotherapy Following Induction Immunochemotherapy for Esophageal Cancer Based on Dynamic ctDNA Monitoring
The Central Hospital of Lishui City · 2 locations · Updated 2026-03-23
SEQUENTIAL PROFILING OF TUMOR-DERIVED CIRCULATING CELL-FREE DNA (ctDNA) IN ADVANCED OVARIAN CANCER PATIENTS
Fondazione Policlinico Universitario Agostino Gemelli IRCCS · 1 locations · Updated 2026-02-11
Prognostic Value of Measuring CtDNA in a Cohort of Patients With Stage III and IV Upper Aero-digestive Tract (UADT) Cancer , Treated With Curative RADiOtherapy With or Without Concomitant Treatment.
Institut de Cancérologie de Lorraine · 7 locations · Updated 2025-12-24
Personalized, Adaptive Treatment for Locally Advanced Head and Neck Cancer
University of Chicago · 1 locations · Updated 2025-06-08
Status can change after this sync. The curated list is the other view on this page. Evidence holds the published results.