Cancer type
Penile
Penile cancer.
Must-know
1
ctDNA in nonmetastatic penile and urethral cancer
Patel et al. JCO Precision Oncology. 2025.
This series reviewed 66 tumor-informed ctDNA tests from 13 patients (7 penile squamous cell carcinoma, 6 primary urethral cancer). Results matched imaging or surgical stage at 65 of 66 time points. The authors describe it as a preliminary report.
A randomized trial was not identified. The report below is a 13-patient series.
Listed when a study is a randomized or prospective interventional ctDNA or MRD trial, is cited in NCCN or ESMO guidance, or is a prospective validation cohort in a high-impact journal. Shorter lists mean fewer studies met that rule. No test is ranked.
Publications and presentations
Presentations
- Level 3prognosticASCO Genitourinary Cancers Symposium 2024
Longitudinal circulating tumor DNA monitoring for detection of molecular residual disease in patients with penile squamous cell carcinoma.
Patel, Mukti · Abstract 11 · 7 patients with advanced HPV-unassociated penile squamous cell carcinoma; single-center retrospective
Signatera (personalized tumor-informed)
Assays were designed for all 7 patients, and ctDNA was detectable at least once in all. Rising ctDNA prompted imaging that showed progression in 3 patients. Two of 7 remained alive with sustained clearance and 3 with persistent positivity had died at the time of the report.
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